The sirtuin theory of aging is one of the most influential — and most debated — frameworks...
Science & Research
Cellular senescence is one of the better-characterized drivers of aging at the cellular level, and senolytics —...
“Reverse your biological age” has become one of the most common claims in the longevity space —...
Nicotinamide riboside has been studied in human clinical trials longer than NMN, and its evidence base is...
NMN’s scientific reputation rests heavily on animal research — compelling mouse studies showing lifespan extension, reversal of...
Metabolic dysfunction — insulin resistance, impaired glucose disposal, disrupted lipid metabolism, and accumulating visceral fat — is...
In 2013, Lopez-Otin and colleagues published a landmark paper in Cell that organized the biology of aging...
DNA is damaged thousands of times per cell per day. Ultraviolet light, reactive oxygen species, replication errors,...
Cognitive decline is among the most feared consequences of aging — and among the most complex to...
Cardiovascular disease remains the leading cause of death in most high-income countries, and its primary drivers —...