Epigenetic clocks estimate your biological age from chemical tags on your DNA called methylation. Horvath’s clock estimates...
Science & Research
Inflammaging is the slow, low-grade inflammation that builds up as we age, even without an infection. Unlike...
Immunosenescence is the gradual decline of immune function with age, and NAD+ biology appears to be part...
The sirtuin theory of aging is one of the most influential — and most debated — frameworks...
Cellular senescence is one of the better-characterized drivers of aging at the cellular level, and senolytics —...
“Reverse your biological age” has become one of the most common claims in the longevity space —...
Nicotinamide riboside has been studied in human clinical trials longer than NMN, and its evidence base is...
NMN’s scientific reputation rests heavily on animal research — compelling mouse studies showing lifespan extension, reversal of...
Metabolic dysfunction — insulin resistance, impaired glucose disposal, disrupted lipid metabolism, and accumulating visceral fat — is...
In 2013, Lopez-Otin and colleagues published a landmark paper in Cell that organized the biology of aging...